2015-03-26 16.39.39

2015-03-26 16.39.39

FEDERICO MAGGI
President
Medical Director
Francesco Ferrer 25/27 Str. – 21052 Busto Arsizio (VA) Italy

+ 39 0331 652911
+ 39 0331 652919
[email protected]
www.tomalab.com
Italiana

From 1975 to 1979
DIAGNOSTIC CYTOLOGY SECTOR ASSAYS LABORATORY
OSPEDALE “C. ONDOLI” ANGERA – VARESE
PUBLIC HOSPITAL EMPLOYEE SECTOR MANAGER

From 1979 to 1983
FACULTY OF MEDICINE AND SURGERY UNIVERSITY OF MILAN
PUBLIC UNIVERSITY
PROFESSIONAL IN CHARGE OF THE EXPERIMENTS IN GENERAL BIOLOGY

From 1979 to 2000
TOMA PRENATAL DIAGNOSIS CENTRE PRIVATE ASSAYS LABORATORY SCIENTIFIC AND TECHNICAL DIRECTOR

From 1990 to 1992
ASSAYS LABORATORY SECTOR
OSPEDALE PROSPIANO – VARESE
PRIVATE HOSPITAL
PROFESSIONAL DIRECTOR

From 2000
TOMA ADVANCED BIOMEDICAL ASSAYS S.P.A.
BIOMEDICAL ANALYSIS LABORATORY – CYTOGENETICS – CLINICAL BIOCHEMISTRY – PATHOLOGICAL ANATOMY – MICROBIOLOGY
PRESIDENT OF THE BOARD OF DIRECTORS AND MEDICAL DIRECTOR

1974
DEGREE IN BIOLOGICAL SCIENCES UNIVERSITY OF PAVIA
University of Pavia
1976
ADMISSION IN THE NATIONAL REGISTER OF BIOLOGISTS
1974
REGIONAL COURSE IN DIAGNOSTIC CYTOLOGY
1978
SPECIALIZATION DIPLOMA IN GENERAL PATHOLOGY
University of Pavia
1982
SPECIALIZATION DIPLOMA IN HUMAN CYTOGENETICS
University of Pavia

More than 70 scientific work published on national and international scientific reviews (see list)

Participation in various national and international congresses

Member of the European Society of Medical Genetics

Member of the Italian Society of Medical Genetics

Member of the scientific committee of Italbioforma – an association whose goal is to propose quality controls for laboratory medicine

Member for many years of the state exam commission for the profession of biologist at the Milan University

He has been vice-president and member of the board of directors of the Luigi Villa Foundation – study centre of molecular pathology applied to clinic – c/o policlinico of milan

From 2011
Member of the board of territory Milano-Brianza Unicredit

From 2010
Member of The Governing Council – Anisap Lombardia

From 2010
member of the scientific committee of Mosaico Onlus

From 2009
Member in the Commission Regione Lombardia (GAT) for the territorial health plan in medical genetics

From 2008
member of the board of directors of holding Biocell Center Spa – Busto Arsizio (Italy– Lugano (Ch) – Boston (Usa)

2005 – 2007
Member of the board of Directors of Polo Scientifico Tecnologico Lombardo Universita’ dell’insubria Varese

2005 – 2007
President of The city council of Arona – (No)

2003 – 2005
Member of the board of directors of ‘Associazione Forestale dei 2 laghi’

1995 – 2004
Mayor of Colazza (No)

Since 1995
Registered in the Journalists Association and Editor in Chief

1993 – 1999
President of Cooperativa ASDA – care home for people with severe disabilities – now he is in the board of directors

1989 – 2000
President of Gife S.A. (CH) – medical analysis laboratory in Lugano

1: Direct chromosome analysis of primary lung and thyroid carcinoma.
XVIII Annual meeting of ESHG: ESSEN,1983.

2: Clinical variability in two not typical cases of Turner Syndrome, Risveglio Ostetrico Vol.1, 1984.

3: Chromosomal analysis with direct method in solid tumours, VII National Congress S.I.C.O.: BOLOGNA, 1984.

4: Cytogenetic evaluation of thyroid neoplasms, thyroid and its pathologies Congress on thyroid and its pathology, Busto Arsizio, 1984.

5: Using the direct method for the cytogenetic analysis of solid tumours, Congress of S.I.S.E.C.M., A.I.G.M.,A.I.C.M., ACIREALE, 1984.

6: Applicability of a direct method for chromosomal analysis of primary solid tumours, Perspectives in Inherited Metabolic disease vol VI, 317-324, 1985.

7: Cytogenetic investigation on peripheral blood lymphocytes in 120 couples with two or more spontaneous abortions. Rivista Ostetrica Ginecologica Perinatale, Vol.1, 1986.

8: Distance and time of CVS are really limiting factors in direct fetal karyiotyping, 7th International Congress of Human Genetic; BERLINO, 1986.

9: Correlation between histopathological characteristics and cytogenetic framework in various types of solid tumours, Two days of Cytogenetics; LEGNANO, 1987.

10: Simoni G, Fraccaro M, Gimelli G, Maggi F, Dagna Bricarelli F. False-positive and false-negative findings on chorionic villus sampling.
Prenat Diagn. 1987 Nov;7(9):671-2. No abstract available.
PMID: 3422916 [PubMed – indexed for MEDLINE]

11: Robertsonian Translocation (13q,14q) in homozygousity, II National Congress F.I.S.M.E.; SIENA, 1987.

12: Primary and secondary chromosomal abnormalities in various tumour types, Conversation on Cytogenetics; LUINO, 1988.

13: Chromosomal abnormalities in various solid tumour types, III National Congress F.I.S.M.E.; ANCONA, 1988.
14: Pericentromeric positive AgNOR variant of a study chromosome in a family, IV National Congress F.I.S.M.E.; MILANO, 1989.

15: Study on the presence of transcribed HLA antigens in cells of Chorial Villi in long term cultures. IV National Congress F.I.S.M.E; MILANO, 1989.

16: Amniotic fluid cell cultures and chromosome analyses before the 15th week of pregnancy, Second European Conference in Gynecology and Obstetrics: MADONNA DI CAMPIGLIO, 1989.

17: Trisomy 16 confined to chorionic villi: what effect on fetal growth and pregnancy? 5th International Congress on Early Fetal Duagnosis. Recent Progress on pubblic health implication; PRAGA, 1990.

18: Fetal Karyiotyping at 6-7 weeks of gestation: on experience of 200 cases, 5th International Congress on Early Fetal Diagnosis. Recent Progress and Pubblic health; PRAGA, 1990.

19: Recurrent chromosomal changes from 19 colorectal tumours, Second European Congress of Human Solid Tumors; LEUVEN, 1990.

20: Trisomy 2 and 16 confined to placenta in 2 pregnancies with fetal hyper-development , V National Congress F.I.S.M.E.; PERUGIA, 1990.

21: Prenatal Paternity testing by DNA Fingerprinting, V Congress Nazionale F.I.S.M.E.; PERUGIA, 1990.

22: Selective reduction of quadruplet pregnancy at risk of B- Thalassemia, The Lancet II, 1325-1326, 1990.

23: Recurrent chromosomal changes from 20 colorectal tumors. Cancer Genetics and Cytogenetics, Vol. 52, 1991.

24: Trisomy 2 confined to the placenta in 2 cases with fetal growth delay. Acta Medica Auxologica, vol.24, 1991.

25: Simoni G, Brambati B, Maggi F, Jackson L.
Trisomy 16 confined to chorionic villi and unfavourable outcome of pregnancy.
Ann Genet. 1992;35(2):110-2.
PMID: 1524407 [PubMed – indexed for MEDLINE]

26: Study on the correlation between placental chromosomal mosaicism and maternal age VI National Congress F.I.S.M.E.; PARMA, 1991.
27: Varicella-Zoster virus infection: prenatal diagnosis with molecular genetics methods: case study Congress of Obstetrics and Gynecological Sciences: PORTOFERRAIO (Isola d’Elba), 1991.

28: Study on the presence of transcribed antigens specific of the major complex of histocompatibility in chorial villi in the first trimester of pregnancy, Seminary “Prenatal diagnosis and genetics of the maternal fetal relationship ";PISA, 1993.

29: Chromosomal analysis with direct method of epidermoid carcinoma of the larynx. Seminary "Cytogenetics of solid tumours"; VARESE , 1994.

30: Definition of structural chromosome alterations, in prenatal stage, through in situ hybridization with biotinylated chromosome specific DNA libraries National Congress FISME, Spoleto, 1994.

31: Giacomini P, Tosi S, Murgia C, Nobili F, Gaetani S, Gambari R, Nicotra MR,Simoni G, Maggi F, Natali PG.
First-trimester human trophoblast is class II major histocompatibility complex
mRNA+/antigen.
Hum Immunol. 1994 Apr;39(4):281-9.
PMID: 8071102 [PubMed – indexed for MEDLINE]

32: Brunelli M, Russo C, Costantini S, Baroli P, Bianchi B, Maggi F.
[Association of the cytogenetic pattern and latero-cervical metastasis of
laryngeal cancer]
Acta Otorhinolaryngol Ital. 1994 Sep-Oct;14(5):553-60. Italian.
PMID: 7856456 [PubMed – indexed for MEDLINE]

33: First trimester chromosome diagnosis using endocervical fluid samples. IV World Congress ISGE joint to II Congress ESGOI-Madonna di Campiglio Feb. 1995.

34: Anomalies of chromosome 9 in the epidermoid carcinoma of the larynx. Molecular and cytogenetic 6 cases study. FISME 1995.

35: Evaluation on the presence of Ethyl Alcohol in the amniotic fluid taken through trans-abdominal amniocentesis. VI Congress on recent developments and applications in pharmaceutical analysis, Milano 21/23 Giugno 1995.

36: Comparison of methods for quantitative determination of Acelofenac in biological liquids. VI Congress on recent developments and applications in pharmaceutical analysis, Milano 21/23 Giugno 1995.
37: HPLC Determinations of amino acids in the amniotic fluid.
VI Congress on recent developments and applications in pharmaceutical analysis, Milano 21/23 Giugno 1995.

38: Early twin amniocentesis by single insertion of the needle.
L’ecografia nella medicina fetale III.Ortisei.Val Gardena. Marzo 1996

39: Genetical investigation of larynx carcinoma.83 Congresso della Societa’ Italiana di Otorinolaringologiae chirurgia cervico-facciale. Milano, 22-25 Maggio 1996.

40: Maggi F, Berdusco F, Liuti R, Trotta A, Testi A, Vadora E, Petrelli M,Calestani V, Simoni G.
First-trimester chromosome diagnosis by lavage of the uterine cavity.
Prenat Diagn. 1996 Sep;16(9):823-7.
PMID: 8905896 [PubMed – indexed for MEDLINE]

41: Report entitled: Research of Toxoplasma genome in amniotic fluid samples. ISTITUTO SUPERIORE DELLA SANITA’, Roma, Ottobre 96.

42: Amino-acids profile in AIDS cachexia: preliminary observation.16 International Congress of Nutrion.Montreal, Canada.27 July-1 August, 1997.

43: Prenatal diagnosis of Parvovirus B19 infection in two foetuses with hydropic abdominal cavity. Giornale di biochimica clinica 1997, Vol.21 pag 77

44: Proinflammatory and regulation citokines in AIDS cachexia.
Second international conference on nutrion and HIV infection. 23/25 April Cannes, France, 1997.

45: Oxygen radicals, antioxidant vitamins and minerals in AIDS cachexia. Second international conference on nutrion and HIV infection. 23/25 April Cannes, France, 1997.

46: Free radicals and oxidative state in patients associated with AIDS cachexia. SINPE, Riunione monotematica ’96, studi clinici controllati in nutrizione artificiale, 1997.

47: Diagnostic application of chorionic villus sample by lavage of uterine cavity. 6th Congress of the the International society of Gynecological Endocrinology, Crans-Montana, Switzerland, March 18-21, 1998.

48: Baroli P, Ruggeri AM, Barlocco A, Maggi F.
[Analysis of a microdeletion in the AZF gene region in azoospermic patients:from research to molecular biology laboratory routine]
Arch Ital Urol Androl. 1998 Apr;70(2):115-8. Italian.
PMID: 9616989 [PubMed – indexed for MEDLINE]
49: Tumor microcirculation and its significance in therapy: possible role of omega-3 fatty acids as rheological modifiers. Medical Hypotheses, 1998, 50, 175-182.

50: chemiluminescensce screening applied to the molecular analysis of Martin-Bell Syndrome. Italian Society of Human Genetics, Congress S.I.G.U, September 30- October 3 1998 Spoleto.

51: Maternal Uniparental Disomy of the chromosome 14 in a foetus with Robertsonian De Novo translocation Italian Society of Human Genetics, Congress S.I.G.U, September 30- October 3 1998 Spoleto.

52: Primed in situ labeling (PRINS): a method for rapid identification and quantification of human chromosomes in both lymphocytes and sperm nuclei. Genome, 41:1-2 (1998).

53: Granata P, Mazzola D, Righi R, Minelli E, Salvatoni A, Baroli P, Maggi F, Casalone R.
Molecular cytogenetics, RFLP analysis and clinical characterization of a de novo trisomy 10p case.
Ann Genet. 2000 Jan-Mar;43(1):45-50. Review.
PMID: 10818221 [PubMed – indexed for MEDLINE]

54: Miller Dieker syndrome consequence of a meiotic recombination of a pericentric inversion of a chromosome 17 of paternal origin, SIGU 2000, Orvieto, Italia

55: Ruggeri A, Dulcetti F, Miozzo M, Grati FR, Grimi B, Bellato S, Natacci F,Maggi F, Simoni G.
Prenatal search for UPD 14 and UPD 15 in 83 cases of familial and de novoheterologous Robertsonian translocations.
Prenat Diagn. 2004 Dec 15;24(12):997-1000.
PMID: 15614836 [PubMed – indexed for MEDLINE]

56: Prenatal diagnosis of a sporadic case of Beckwith-Wiedemann syndrome. (SIGU 2004) Frate E, Baldo D, De Nardi A, Maggi F., Bracalente G, Turolla L.

57: Risk evaluation of foetal mosaicism and uniparental disomy associated with numerical chromosome and mosaic placental structural alterations.
(SIGU2004) B. Grimi1, F.R. Grati1,2, F. Dulcetti1, A.M. Di Meco1, G. Frascoli1, R. Liuti1, A. Trotta1, S. Milani1, M. Miozzo2, F. Maggi1, G. Simoni1,2.

58: Pure partial trisomy and partial monosomy of the 13q22.3q32.1 region following paternal translocation insertion between chromosome 3 and 13 (Sigu 2005). Carelle F, Crespi L, Chinetti S, Maggi F and Grati FR

59: Grati FR, Grimi B, Frascoli G, Di Meco AM, Liuti R, Milani S, Trotta A,Dulcetti F, Grosso E, Miozzo M, Maggi F, Simoni G. Confirmation of mosaicism and uniparental disomy in amniocytes, after detection of mosaic chromosome abnormalities in chorionic villi.
Eur J Hum Genet. 2006 Mar;14(3):282-8.
PMID: 16418738 [PubMed – indexed for MEDLINE]

60: Simona De Toffol1 Francesca Dulcetti1, Anna Ruggeri1, Silvia Milani1,Sara Chinetti1, Anna Maria Di Meco1, Federico Maggi1, Giuseppe Simoni1, Francesca Romana Grati1.
STUDY ON ABORTIVE TISSUES WITH MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION (MLPA) WITH SUBTELOMERIC PROBES
SIGU –Lido di Venezia 2006

61: Simona De Toffol1, Francesca Dulcetti1, Anna Ruggeri1, Beatrice Grimi1, Rosaria Liuti1, Silvia Paganini1,Federico Maggi1, Giuseppe Simoni1, Francesca Romana Grati1.
PRENATAL IDENTIFICATION OF DUPLICATION OF THE TELOMERIC REGION 20P WITH MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION (MLPA)
SIGU – Venice Lido 2006

62: Francesca Romana Grati1, Anna Trotta1, Giuditta Frascoli1, Cristina Agrati1, Simona De Toffol1, Federico Maggi1, Giuseppe Simoni1
MOLECULAR CHARACTERIZATION IN A CASE OF UNBALANCED MUTUAL TRANSLOCATION T(4;20)(Q26;P11.2) DE NOVO IN UN FOETUS WITH GROWTH RETARDTION AND CARDIAC MALFORMATIONS.
SIGU –Venice Lido 2006

63: F.Bolda, A.Lanfranchi, E.Mattarucchi, G.Simoni, Federico Maggi, F.R.Grati, F.Pasquali, G.Porta, F.Porta.
MESENCHYMAL STEM CELLS FROM AMNIOTIC FLUID AS CELL THERAPY?
SIGU –Venice Lido 2006

64: F.R. Grati , B.Grimi, F.Dulcetti , B.Malvestiti, G.Frascoli, S.De Toffol, A.M.Di Meco, A.M.Ruggeri, R.Liuti, S.Milani, A.Trotta, Federico Maggi, G.Simoni.
APPLICATION OF THE QF-PCR ON NATIVE CHORIAL VILLI IN CASES OF FAILURE OF THE LONG TERM CULTURE AS A SUPPORT FOR THE IDENTIFICATION OF THE FALSE-NEGATIVE AND FALSE-POSITIVE
SIGU – Montecatini 2007

65: E.Sanna, M.Manganini, F.R. Grati, S.Chinetti, E.Bernardi, S.Bianchi, E.Iantosca, E.Menzaghi, L.Diolosà, S.Bernasconi, Federico Maggi, G.Simoni.
CORRELATION BETWEEN THE MESENCHYMAL STEM CELLS MARKER EXPRESSION AND THE MORPHOLOGY OF THE AMNIOCYTES IN VARIOUS STAGES OF PREGNANCY
SIGU – Montecatini 2007

66: S.De Toffol, F.Dulcetti, A.M.Ruggeri, , P.P.Maggio, Federico Maggi, G.Simoni, F.R. Grati. STUDY ON A FAMILY WITH CHARCHOT MARIE TOOTH TYPE 1 WITH MULTIPLEX LIGATION-DEPENDENT PROBEAMPLIFICATION (MLPA).
SIGU – Montecatini 2007

67: B.Malvestiti, F.Dulcetti, A.M.Ruggeri, S.De Toffol, A.Maggioni, M.Dilernia, Federico Maggi, G.Simoni, F.R. Grati. SEARCH OF THE GREAT REARRANGEMENTS OF THE CFTR GENE IN COUPLES INCLUDED IN MEDICAL ASSISTED PROCREATION PROGRAMS .
SIGU – Montecatini 2007

68: S.De Toffol, B.Malvestiti, F.Dulcetti, A.Ruggeri, A.Maggioni, M.Di Lernia, Federico Maggi, G.Simoni, F.R.Grati . INVESTIGATION OF CFTR EXONIC REARRANGEMENTS IN INFERTILE COUPLES. XIII CONGRESSO ITALIANO DELLA FIBROSI CISTICA (SIFC) Milano 30 Novembre – 2 Dicembre 2007

69: Chromosome abberrations investigated by non-invasive prenatal testing account for approximately 50% of fetal chromosomal abnormalities associated with relevant clinical phenotypes AMERICAN JOURNAL OF MEDICAL GENETICS
Francesca Romana Grati1, Andrea Barlocco1, Beatrice Grimi1, Silvia Milani1, Giuditta Frascoli1, Anna Maria Di Meco 1, Rosaria Liuti1, Anna Trotta1, Sara Chinetti1, Francesca Dulcetti1, Anna Maria Ruggeri1, Simona De Toffol1, Maurizio Clementi2, Federico Maggi1, Giuseppe Simoni1

70: Prenatal diagnosis of del(4)(q27q31.23), due to a maternal balanced complex chromosome rearrangement, characterized by array-CGH.
Prenat Diagn. 2010 Mar;30(3):280-3. No abstract available. PMID: 20049850 [PubMed – in processRelated articles
Francesca Malvestiti1* , Simona De Toffol1, Sara Chinetti1, Beatrice Grimi1, Giancarlo Favero2, Alessandro Borsatti3, Federico Maggi1, Giuseppe Simoni1 and Francesca Romana Grati1

71: Quantitative Fluorescence-Polymerase Chain Reaction Assay for the Detection of the Duplication of the Charcot Marie Tooth Disease Type 1A Critical Region.
Genet Test Mol Biomarkers. 2010 Feb 28. [Epub ahead of print]PMID: 20187762 [PubMed – as supplied by publisher]Related articles
Simona De Toffol 1, Emilia Bellone 2, Francesca Dulcetti 1, Anna Maria Ruggeri 1, Pietro Paolo Maggio 3, Maria Rosaria Pulimeno 4, Paola Mandich 2, Federico Maggi 1, Giuseppe Simoni 1, Francesca Romana Grati 1.

72: Pure Monosomy and Pure Trisomy of 13q21.2->31.1 Consequent to a Familial Insertional Translocation: Exclusion of PCDH9 as the Responsible Gene for Autosomal Dominant Auditory Neuropathy (AUNA1). Am J Med Genet A. 2009 May;149A(5):906-13. (IF anno 2008: 2.555)

Francesca R. Grati, Marci M. Lesperance, Simona De Toffol, Sara Chinetti, Angelo Selicorni, Sarah Emery, Beatrice Grimi, Francesca Dulcetti, Barbara Malvestiti, Joseph Taylor, Silvia Milani, Anna M. Ruggeri, Federico Maggi, Giuseppe Simoni.

73: Prenatal detection by subtelomeric FISH and MLPA of unbalanced meiotic recombinants resulting from parental pericentric inversions Mol Cell Probes. 2008 Oct-Dec;22(5-6):316-9. (IF anno 2008: 2.196)

Grati FR, Chinetti S, Malgara R, Rognoni G, Grimi B, De Toffol S, Milani S, Dulcetti F, Frascoli G, Di Meco AM, Liuti R, Trotta A, Coffa J, Maggi F, G.Simoni.